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Revolutionizing the Treatment of Central Nervous System Conditions

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Realeve is dedicated to developing innovative treatment systems that target diseases and conditions of the central nervous system (CNS) by controlling the SPG (sphenopalatine ganglion) using groundbreaking technology called the PulsanteTM  micro-neurostimulator system.

This system is the first-ever externally powered implantable micro-neuromodulation device. It has already been successfully implanted in over 700 patients, with documented long-term effectiveness in achieving disease-modifying effects specifically for the treatment of cluster headaches.

Realeve's mission is to advance the field of neuroscience and provide effective treatments for CNS disorders using the ground-breaking Pulsante system and its demonstrated positive impact on patients' lives.

Introducing Our Patented Pulsante Micro-Neurostimulation Implant and Transmitter.

Pulsante implant

The PulsanteTM Implant features a battery-free, wireless compact SPG microstimulation implant. This device can be surgically inserted with minimal invasiveness. The implant's activation is triggered when the patient brings the RC-200 handheld device to the designated implant area.

Pulsante RC-200

The PulsanteTM RC-200 Device emits variable radiowave frequencies which power the Pulsante Implant to treat a range of brain-related conditions. Our advanced technology incorporates additional data collection capabilities that enable continuous monitoring of patient treatment and outcomes.

Pulsante Applications

Blood -Brain barrier

A crucial immunological feature of the human central nervous system (CNS). The BBB is both a structural and functional roadblock to microorganisms that may be circulating in the bloodstream.

Acute ischemic stroke

An ischemic stroke occurs when the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients.

Cluster headaches

A cluster headache is an uncommon type of headache. It is one-sided head pain that may involve tearing of the eyes, a droopy eyelid, and a stuffy nose. Attacks last from 15 minutes to 3hours, occur daily or almost daily for weeks or months

Proprietary ASIC Technology

Application Specific Integrated Circuit is a non-standard integrated circuit designed for a specific use or application. Realeve uses a custom ASIC handle bidirectional communication, power, and therapy.

Blood-Brain Barrier

A crucial immunological feature of the human central nervous system (CNS). The BBB is both a structural and functional roadblock to microorganisms that may be circulating in the bloodstream.
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SPG stimulation significantly increased blood-brain barrier (BBB) permeability in rat models, an effect that was reversible and potentially linked to disruptions in tight junction morphology
StudyAdditional Readings

Ischemic Stroke

An ischemic stroke occurs when the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients.
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Sphenopalatine ganglion stimulation (SPG-Stim) improved outcomes for acute ischemic stroke patients when started 8–24 hours post-onset
StudyAdditional Readings

Cluster Headaches

A cluster headache is an uncommon type of headache. It is one-sided head pain that may involve tearing of the eyes, a droopy eyelid, and a stuffy nose. Attacks last from 15 minutes to 3hours, occur daily or almost daily for weeks or months
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Patients receiving sphenopalatine ganglion stimulation experienced a 62.46% rate of pain relief at 15 minutes, compared to 38.87% in the control group
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StudyAdditional Readings
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How SPG Stim Works

Minimally invasive surgical procedure to access the SPG without visible scars.

Neuromodulation signals are directed at the SPG

Therapy is activated and controlled by the patient with a wireless remote controller

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Dr. Peter Bonutti Recognized as One of the USA’s Most Trusted Orthopedic Surgeons

Realeve is proud to announce that our founder and CEO, Dr. Peter Bonutti, has been named one of USA’s 5 Most Trusted Orthopedic Surgeons by Insights Care magazine.

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January 29, 2025
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Realeve Wins Gold in 2023 Merit Awards for Healthcare

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March 6, 2024
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Realeve is issued US and EU patents

Realeve has been issued three additional patents in the US and Europe. US 11,679,263 SYSTEMS AND METHODS FOR IMPROVING HEADACHE PAIN Issued on June 20, 2023 EP 3386583 SURGICAL TOOLS…

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August 30, 2023