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Advancing treatment of conditions related to the brain

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Realeve’s mission is to develop novel treatment systems for treating diseases and conditions of the CNS by controlling the SPG via the Pulsante micro-neurostimulator system.
The Pulsante System is the first externally powered implantable micro-neuromodulation device with over 700 Patients implanted, with documented long-term success with Disease Modifying effects for the treatment of cluster headaches.

Pulsante implant

Miniature, Battery-Free SPG Microstimulation Implant that can be surgically inserted in a patient in a minimally invasive outpatient surgery. The implant is activated when a patient brings the RC-200 hand held to the Implant Area.

Pulsante RC-200

The Pulsante RC-200 emits variable Radiowave Frequencies to achieve different outcomes within a patient that may treat a multitude of conditions that are related to the brain. Additional data collection capabilities present the ability to monitor patient treatment and outcomes throughout the course of treatment.

Pulsante Applications

Blood -Brain barrier

A crucial immunological feature of the human central nervous system (CNS). The BBB is both a structural and functional roadblock to microorganisms that may be circulating in the bloodstream.

Acute ischemic stroke

An ischemic stroke occurs when the blood supply to part of the brain is interrupted or reduced, preventing brain tissue from getting oxygen and nutrients.

Cluster headaches

A cluster headache is an uncommon type of headache. It is one-sided head pain that may involve tearing of the eyes, a droopy eyelid, and a stuffy nose. Attacks last from 15 minutes to 3hours, occur daily or almost daily for weeks or months

Proprietary ASIC Technology

Application Specific Integrated Circuit is a non-standard integrated circuit designed for a specific use or application. Realeve uses a custom ASIC handle bidirectional communication, power, and therapy.

Blood-Brain Barrier

SPG stimulation significantly increased blood-brain barrier (BBB) permeability in rat models, an effect that was reversible and potentially linked to disruptions in tight junction morphology
StudyAdditional Readings

Ischemic Stroke

Sphenopalatine ganglion stimulation (SPG-Stim) improved outcomes for acute ischemic stroke patients when started 8–24 hours post-onset
StudyAdditional Readings

Cluster Headaches

Patients receiving sphenopalatine ganglion stimulation experienced a 62.46% rate of pain relief at 15 minutes, compared to 38.87% in the control group
StudyAdditional Readings
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How SPG Stim Works

Minimally invasive surgical procedure to access the SPG without visible scars.

Neuromodulation signals are directed at the SPG

Therapy is activated and controlled by the patient with a wireless remote controller

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